Int J Clin Pharmacol Ther. Some antacids can make it harder for your body to absorb rosuvastatin. If you already have type 2 diabetes, your doctor may advise monitoring your blood sugar levels more closely for the first few months. Atorvastatin Study Group I. Get emergency medical help if you have any signs of an allergic reaction to Crestor: hives; difficult breathing; swelling of your face, lips, tongue, or throat. International Journal of Endocrinology and Metabolism: 15 2 ; e Safety and efficacy of statins in Asians.
Rosuvastatin and atorvastatin are the only statins to form a hydrogen bond with the hydroxyl group of Ser on HMG-CoA reductase enzyme. Patient resources Patient counselling is advised for rosuvastatin tablets muscle effects. Increased systemic exposure to rosuvastatin in Asian subjects residing in the United States compared to Caucasian subjects. The functional difference between natural and synthetic statins relies on their ability to interact and inhibit the HMG-CoA reductase and on their hydrophobicity. Comparison of rosuvastatin and atorvastatin for lipid lowering in patients with type 2 diabetes mellitus: results from the URANUS study.
Keep taking rosuvastatin even if you feel well, as you'll still be getting the benefits. FDA alerts for all medications. Some Internet browsers offer what often is referred to as "do-not-track" mechanisms for browser users to automatically signal privacy preferences to websites that they visit. Do not breast-feed while you are taking this medicine. The subject has not met LDL-C treatment goals. While the more hydrophilic statins such as rosuvastatin and pravastatin, active transport is the main mode of entry into the liver, they are metabolised less by the CYP enzymes and actively excreted through the kidneys.
This is not a complete list of side effects and others may occur. How does rosuvastatin work? Statins are thought to have very few side effects. First, the fluorinated phenyl group and a polar methane sulphonamide group of rosuvastatin provide multiple sites of activity against HMG-CoA reductase Use in Pregnancy and Lactation Rosuvastatin should be administered to women of childbearing age only when such patients are highly unlikely to conceive and have been informed of the potential hazards.